| Assay ID | Title | Year | Journal | Article |
|---|
| AID514142 | Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. |
| AID411271 | Growth inhibition of wild type wild type Saccharomyces cerevisiae SB819 at 0.2 to 1 mM after 48 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID1067291 | Growth inhibition of Saccharomyces cerevisiae BY4742 harboring gcn5delta mutant at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID1143395 | Inhibition of recombinant human p300 catalytic domain (1284 to 1673 aa) using histone H3 at 100 uM after 1 hr by radiochemical assay in presence of [acetyl-3H]-acetyl coenzyme A | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies. |
| AID514141 | Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. |
| AID308421 | Antifungal activity against Candida albicans after 24 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID411275 | Inhibition of human recombinant Gcn5 assessed as reduction in acetylated histone H3 level at 0.8 mM by Western blot analysis in presence of 200 ng histone H3 | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID411276 | Inhibition of human recombinant Gcn5 assessed as reduction in acetylated histone H3 level at 0.8 mM by Western blot analysis in presence of increased concentration of acetyl-CoA | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID1067295 | Reduction of growth of Saccharomyces cerevisiae harboring gcn5delta mutant at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID308429 | Cytotoxicity against human EAhy926 cells assessed as cell survival fraction at 0.5 ug/ml after 24 hrs by trypan blue exclusion test | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID308428 | Cytotoxicity against human EAhy926 cells assessed as cell survival fraction at 5 ug/ml after 24 hrs by trypan blue exclusion test | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID308427 | Cytotoxicity against human EAhy926 cells assessed as cell survival fraction at 50 ug/ml after 24 hrs by trypan blue exclusion test | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID1067292 | Growth inhibition of Saccharomyces cerevisiae S288c harboring gcn5delta mutant at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID514145 | Selectivity ratio of IC50 for human recombinant MAOA to IC50 for human recombinant MAOB | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. |
| AID1067288 | Growth inhibition of Saccharomyces cerevisiae S288c harboring elp3delta mutant at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID411270 | Growth inhibition of Saccharomyces cerevisiae SB0-deltabr mutant at 0.2 to 1 mM after 48 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID308422 | Antifungal activity against Candida glabrata after 24 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID411269 | Growth inhibition of Saccharomyces cerevisiae gcn5E173H mutant at 0.2 to 1 mM after 48 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID411272 | Inhibition of human recombinant Gcn5 assessed as reduction in acetylated histone H3 level at 0.8 mM by Western blot analysis | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID1143396 | Inhibition of recombinant human p300 catalytic domain (1284 to 1673 aa) using histone H3 at 200 uM after 1 hr by radiochemical assay in presence of [acetyl-3H]-acetyl coenzyme A | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies. |
| AID1067297 | Reduction of wild type Saccharomyces cerevisiae growth at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID411267 | Growth inhibition of Saccharomyces cerevisiae sas2delta mutant at 0.2 to 1 mM after 72 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID1067287 | Growth inhibition of Saccharomyces cerevisiae BY4742 harboring rtt109delta mutant at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID411278 | Decrease in global histone H3 acetylation in wild type Saccharomyces cerevisiae S288C at 0.8 mM after 24 hrs at 28 degC by hybridization assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID411265 | Growth inhibition of Saccharomyces cerevisiae gcn5delta mutant at 0.2 to 1 mM after 72 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID308430 | Cytotoxicity against human EAhy926 cells assessed as cell survival fraction at 0.05 ug/ml after 24 hrs by trypan blue exclusion test | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID411282 | Inhibition of histone H3 acetylation at H3-AcK14 site in Saccharomyces cerevisiae gcn5delta mutant at 0.8 mM after 24 hrs at 28 degC by hybridization assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID1143398 | Inhibition of recombinant human PCAF catalytic domain (492 to 658 aa) using histone H3 at 100 uM after 1 hr by radiochemical assay in presence of [acetyl-3H]-acetyl coenzyme A | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies. |
| AID308425 | Antifungal activity against Candida parapsilosis after 24 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID411281 | Inhibition of global histone H3 acetylation in Saccharomyces cerevisiae gcn5delta mutant at 0.8 mM after 24 hrs at 28 degC by hybridization assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID308424 | Antifungal activity against Candida krusei after 24 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID1143397 | Inhibition of recombinant human p300 catalytic domain (1284 to 1673 aa) using histone H3 at 400 uM after 1 hr by radiochemical assay in presence of [acetyl-3H]-acetyl coenzyme A | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies. |
| AID411280 | Inhibition of histone H3 acetylation at H3-AcK14 site in wild type Saccharomyces cerevisiae S288C at 0.8 mM after 24 hrs at 28 degC by hybridization assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID1067286 | Growth inhibition of Saccharomyces cerevisiae S288c harboring sas2delta mutant at 0.5 mM after 48 hrs | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. |
| AID411268 | Growth inhibition of Saccharomyces cerevisiae gcn5delta mutant at 0.2 to 1 mM after 48 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID411279 | Reduction of global histone H4 acetylation in wild type Saccharomyces cerevisiae S288C at 0.8 mM after 24 hrs at 28 degC by hybridization assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID411274 | Inhibition of human recombinant Gcn5 assessed as reduction in acetylated histone H3 level at 0.8 mM by Western blot analysis in presence of 100 ng histone H3 | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| AID308423 | Antifungal activity against Candida tropicalis after 24 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID308426 | Antifungal activity against Candida sake after 24 hrs by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. |
| AID411266 | Growth inhibition of Saccharomyces cerevisiae elp3delta mutant at 0.2 to 1 mM after 72 hrs at 28 degC by growth spot assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |